Is There A Prognostic Significance For Copper, Beryllium, Boron, Titanium And Vanadium Ions In Prostate Cancer?

Aim: There are several epidemiological, clinical and experimental studies that relate heavy metal exposure to Prostatic adenocarcinoma (PCa). In this study, the relationship between benign prostatic hyperplasia (BPH) PCa, some metal/nonmetal concentrations at level of histopathological diagnosis was investigated. Materials Methods: Seventy-one patients were included in study. The samples taken from paraffin blocks subjected microwave digestion, analyzed via Inductively coupled plasma mass spectrometry (ICP-MS) determine tissue platinum, thallium, lead, molybdenum, cadmium, selenium77, selenium82, iron, potassium, lithium, beryllium, boron, sodium, magnesium, phosphorus, calcium, titanium, vanadium, chromium, manganese, cobalt, nickel, copper, zinc, arsenic, strontium, tin, antimony. findings with SPSS. Results: When levels prostate examined BPH malignant patient groups, a statistically significant difference found lithium (p=0.006), beryllium (p=0.02), boron (p=0.001), sodium (p=0.009), magnesium phosphorus calcium titanium (p=0.004), vanadium chromium (p=0.04), manganese cobalt (p=0.003), nickel (p=0.005), copper (p=0.019), zinc arsenic (p=0.002),strontium tin (p=0.002) antimony (p=0.001). Beryllium, least five times higher tissues. compared according new Gleason prognostic grade grouping, positive correlation (p = 0.02). Conclusion: This study showed or more hyperplasia. It also histological increased increasing concentration. Metal should be considered for prognosis PCa.